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Article

The CTLA4 +49 A/GG-CT60G haplotype is associated with susceptibility to multiple sclerosis in Flanders.

Journal of neuroimmunology - 1 Jul 2005

Suppiah V, Alloza I, Heggarty S, Goris A, Dubois B, Carton H, Vandenbroeck K

Abstract excerpt

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system white matter characterized by inflammation, demyelination and axonal damage. The cytotoxic T lymphocyte antigen-4 (CTLA-4) protein plays a key role in the down-regulation of T cell activation. We analysed the CTLA4 +49A/G and CT60 polymorphisms in a cohort of 120 MS trio families recruited from the Flanders region in Belgium....

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Source

Identifiers

PMID: 15904974
DOI: 10.1016/j.jneuroim.2005.04.003

Genes

CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The CTLA4 +49 A/G*G-CT60*G haplotype is associated with susceptibility to multiple sclerosis in Flanders.PMID 15904974Read ↗

CTLA-4 +49 A/G gene polymorphism in Croatian and Slovenian multiple sclerosis patients.Semantic proximity Read ↗

Multiple sclerosis and the CTLA4 autoimmunity polymorphism CT60: no association in patients from Germany, Hungary and Poland.Semantic proximity Read ↗

The CTLA-4 gene is associated with multiple sclerosis.Semantic proximity Read ↗

CTLA4 gene polymorphisms and multiple sclerosis in Northern Ireland.Semantic proximity Read ↗

CTLA-4 gene and the susceptibility of multiple sclerosis: an updated meta-analysis study including 12,916 cases and 15,455 controls.Semantic proximity Read ↗

CTLA4 +49 A/G and CT60 polymorphisms in Dutch coeliac disease patients.Semantic proximity Read ↗

The CTLA-4 gene polymorphisms are associated with CTLA-4 protein expression levels in multiple sclerosis patients and with susceptibility to disease.Semantic proximity Read ↗

CTLA4 exon 1 dimorphism is associated with primary progressive multiple sclerosis.Semantic proximity Read ↗

Distribution of the CTLA-4 single nucleotide polymorphisms CT60G>A and +49A>G in psoriasis vulgaris patients and control individuals from a Polish Caucasian population.Semantic proximity Read ↗

No evidence of a significant role for CTLA-4 in multiple sclerosis.Semantic proximity Read ↗

CT60 genotype does not affect CTLA-4 isoform expression despite association to T1D and AITD in northern Sweden.Semantic proximity Read ↗

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