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Article

Temporal phosphorylation of the Drosophila period protein.

Proceedings of the National Academy of Sciences of the United States of America - 15 Mar 1994

Edery I, Zwiebel L J, Dembinska M E, Rosbash M

Abstract excerpt

The period gene (per) is required for Drosophila melanogaster to manifest circadian (congruent to 24 hr) rhythms. We report here that per protein (PER) undergoes daily oscillations in apparent molecular mass as well as abundance. The mobility changes are largely or exclusively due to multiple phosphorylation events. The temporal profile of the classic short-period form of PER (PERS) is altered in a manner...

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Identifiers

PMID: 8134384
DOI: 10.1073/pnas.91.6.2260
PMCID: PMC43350

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