Article
A small conserved domain of Drosophila PERIOD is important for circadian phosphorylation, nuclear localization, and transcriptional repressor activity.
Molecular and cellular biology - 1 Jul 2007
Nawathean Pipat, Stoleru Dan, Rosbash Michael
Abstract excerpt
We identify in this study a 27-amino-acid motif which is conserved between the Drosophila melanogaster period protein (PER) and the three mammalian PERs. Characterization of PER lacking this motif (PER Delta) shows that it is important for phosphorylation of Drosophila PER by casein kinase I epsilon (CKI epsilon; doubletime protein or DBT) and CKII. S2 cell assays indicate that the domain also contributes...
Topics
- Active Transport, Cell Nucleus
- Amino Acid Sequence
- Animals
- Cell Nucleus
- Circadian Rhythm
- Conserved Sequence
- Drosophila Proteins
- Drosophila melanogaster
- Models, Biological
- Molecular Sequence Data
- Motor Activity
- Mutagenesis
- Mutant Proteins