Article
On the genetic involvement of apoptosis-related genes in Crohn's disease as revealed by an extended association screen using 245 markers: no evidence for new predisposing factors.
Journal of negative results in biomedicine - 30 Nov 2005
Wagenleiter Sonja E N, Jagiello Peter, Akkad Denis A, Arning Larissa, Griga Thomas, Klein Wolfram, Epplen Jörg T
Abstract excerpt
Crohn's disease (CD) presents as an inflammatory barrier disease with characteristic destructive processes in the intestinal wall. Although the pathomechanisms of CD are still not exactly understood, there is evidence that, in addition to e.g. bacterial colonisation, genetic predisposition contributes to the development of CD. In order to search for predisposing genetic factors we scrutinised 245 microsatellite...
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