Article
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease.
Nature - 31 May 2001
Hugot J P, Chamaillard M, Zouali H, Lesage S, Cézard J P, Belaiche J, Almer S, Tysk C, O'Morain C A, Gassull M, Binder V, Finkel Y, Cortot A, Modigliani R, Laurent-Puig P, Gower-Rousseau C, Macry J, Colombel J F, Sahbatou M, Thomas G
Abstract excerpt
Crohn's disease and ulcerative colitis, the two main types of chronic inflammatory bowel disease, are multifactorial conditions of unknown aetiology. A susceptibility locus for Crohn's disease has been mapped to chromosome 16. Here we have used a positional-cloning strategy, based on linkage analysis followed by linkage disequilibrium mapping, to identify three independent associations for Crohn's disease: a...
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