Article
Crohn disease: susceptibility and disease heterogeneity revealed by HLA genotyping.
Human immunology - 1 Jul 2001
Lombardi M L, Pirozzi G, Luongo V, Mercuro O, Pace E, Blanco Del Vecchio G, Cozzolino A, Errico S, Fusco C, Castiglione F
Abstract excerpt
Predisposition to Crohn disease (CD) seems to be genetically determined but, though several reports on the matter, the association between HLA antigens and the disease is still controversial. PCR-SSP high resolution typing in 107 CD patients, and in subgroups selected according to clinical features, showed a positive association with the rare haplotype DRB1*07, DQB1*0303 both in the overall patients (p = 0.002;...
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