Article
Evaluation of polymorphic variants in apoptotic genes and their role in susceptibility and clinical progression to systemic lupus erythematosus.
Lupus - 1 Jun 2017
Glesse N, Vianna P, Paim L M G, Matte M C C, Aguiar A K K, Palhano P L, Monticielo O A, Brenol C V, Xavier R M, Chies J A B
Abstract excerpt
Background Systemic lupus erythematosus (SLE) is an autoimmune disease marked by the disruption of the immune homeostasis. Patients exhibit a wide range of clinical manifestations, and environmental and genetic factors are involved in SLE pathogenesis. Evidence suggests that abnormalities in the cellular and molecular events that coordinate apoptosis may favour the generation of autoantigens involved in...
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