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Retrospective evaluation of risk-reducing salpingo-oophorectomy for BRCA1/2 pathogenic variant carriers among a cohort study in a single institution.

Japanese journal of clinical oncology - 8 Feb 2021

Kobayashi Yusuke, Hirasawa Akira, Chiyoda Tatsuyuki, Ueki Arisa, Masuda Kenta, Misu Kumiko, Kawaida Miho, Hayashi Shigenori, Kataoka Fumio, Banno Kouji, Kosaki Kenjiro, Aoki Daisuke

Abstract excerpt

BACKGROUND: Risk-reducing salpingo-oophorectomy is performed for the primary prevention of ovarian cancer in patients with hereditary breast-ovarian cancer syndrome. We performed risk-reducing salpingo-oophorectomy for the first time in Japan in 2008, and we experienced 20 cases of risk-reducing salpingo-oophorectomy through 2019. In the past, the use of risk-reducing salpingo-oophorectomy in Japan was restricted...

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PMID: 33037428
DOI: 10.1093/jjco/hyaa173

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