Article
Evaluation of arrayed primer extension for TP53 mutation detection in breast and ovarian carcinomas.
BioTechniques - 1 Nov 2005
Kringen Pedro, Bergamaschi Anna, Due Eldri Undlien, Wang Yun, Tagliabue Elda, Nesland Jahn M, Nehman Aune, Tönisson Neeme, Børresen-Dale Anne-Lise
Abstract excerpt
Mutations in the tumor suppressor gene TP53 are associated with a wide range of different cancers and may have prognostic and therapeutic implications. Methods for rapid and sensitive detection of mutations in this gene are therefore required. In order to make screening more effective, a commercially available TP53 genotyping microarray from Asper Biotech has been constructed by arrayed primer extension (APEX)....
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