Article
Development of a single tube 640-plex genotyping method for detection of nucleic acid variations on microarrays.
Nucleic acids research - 1 Jul 2008
Krjutskov Kaarel, Andreson Reidar, Mägi Reedik, Nikopensius Tiit, Khrunin Andrey, Mihailov Evelin, Tammekivi Veronika, Sork Helena, Remm Maido, Metspalu Andres
Abstract excerpt
Detection of DNA sequence variation is critical to biomedical applications, including disease genetic identification, diagnosis and treatment, drug discovery and forensic analysis. Here, we describe an arrayed primer extension-based genotyping method (APEX-2) that allows multiplex (640-plex) DNA amplification and detection of single nucleotide polymorphisms (SNPs) and mutations on microarrays via four-color...
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