Article
APEX disease gene resequencing: mutations in exon 7 of the p53 tumor suppressor gene.
Bioorganic & medicinal chemistry - 1 Sept 2001
Shumaker J M, Tollet J J, Filbin K J, Montague-Smith M P, Pirrung M C
Abstract excerpt
Detection of mutations in disease genes will be a significant application of genomic research. Methods for detecting mutations at the single nucleotide level are required in highly mutated genes such as the tumor suppressor p53. Resequencing of an individual patient's DNA by conventional Sanger methods is impractical, calling for novel methods for sequence analysis. Toward this end, an arrayed primer extension...
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