Article
Evaluating the arrayed primer extension resequencing assay of TP53 tumor suppressor gene.
Proceedings of the National Academy of Sciences of the United States of America - 16 Apr 2002
Tõnisson Neeme, Zernant Jana, Kurg Ants, Pavel Hendrik, Slavin Georg, Roomere Hanno, Meiel Aune, Hainaut Pierre, Metspalu Andres
Abstract excerpt
Identification of mutations in the tumor suppressor gene TP53 has implications for the molecular epidemiology and for the molecular pathology of human cancer. We have developed and evaluated an arrayed primer extension assay for covering both strands of a region of the coding sequence containing more than 95% of the mutations described so far in TP53. On average, 97.5% of the arrayed TP53 gene sequence can be...
Topics
- Algorithms
- Codon
- DNA Mutational Analysis
- Exons
- Genes, p53
- Genetic Techniques
- Humans
- Introns
- Mutation
- Mutation, Missense
- Oligonucleotide Array Sequence Analysis