Article
Detection of single base alterations in genomic DNA by solid phase polymerase chain reaction on oligonucleotide microarrays.
Analytical biochemistry - 1 Dec 2001
Huber M, Losert D, Hiller R, Harwanegg C, Mueller M W, Schmidt W M
Abstract excerpt
DNA microarray technology holds significant promise for human DNA diagnostics. A number of technical approaches directed at the parallel identification of mutations or single nucleotide polymorphisms make use of polymerase-based specificity, like minisequencing or allele-specific primer elongation. These techniques, however, require separate laborious sample amplification, preparation, and purification steps,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.