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Article

Evolution of major histocompatibility complex class II allelic diversity: direct descent in mice and humans.

Proceedings of the National Academy of Sciences of the United States of America - 15 Jul 1992

Lundberg A S, McDevitt H O

Abstract excerpt

The high degree of polymorphism seen at major histocompatibility complex (MHC) class II loci is a feature unique to the MHC. Most of the beta-chain polymorphism is localized in "hypervariable" regions (HVRs). HVR amino acid sequence similarity between distantly related species has recently been found. We have employed a Monte-Carlo statistic to show that shared HVR polymorphism between beta-chain genes of humans...

Topics

Alleles
Amino Acid Sequence
Animals
Base Sequence
Biological Evolution
Genes, MHC Class II
Humans
Mice
Molecular Sequence Data
Monte Carlo Method
Polymorphism, Genetic

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Identifiers

PMID: 1631156
DOI: 10.1073/pnas.89.14.6545
PMCID: PMC49538

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1631156-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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