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Article

Role of diversifying selection and gene conversion in evolution of major histocompatibility complex loci.

Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1991

Ohta T

Abstract excerpt

Genes at the major histocompatibility complex (MHC) in mammals are known to have exceptionally high polymorphism and linkage disequilibrium. In addition, these genes form highly complicated gene families that have evolved through gene conversion and unequal crossing-over. It has been shown recent...

Topics

Alleles
Animals
Biological Evolution
Gene Conversion
Genetic Variation
Humans
Major Histocompatibility Complex
Mathematics
Mice
Models, Genetic
Multigene Family
Selection, Genetic

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Identifiers

PMID: 1862096
DOI: 10.1073/pnas.88.15.6716
PMCID: PMC52159

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1862096-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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