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Article

Role of diversifying selection and gene conversion in evolution of major histocompatibility complex loci.

Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1991

Ohta T

Abstract excerpt

Genes at the major histocompatibility complex (MHC) in mammals are known to have exceptionally high polymorphism and linkage disequilibrium. In addition, these genes form highly complicated gene families that have evolved through gene conversion and unequal crossing-over. It has been shown recently that amino acid substitution at the antigen recognition site (ARS) is more rapid than synonymous substitution,...

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Identifiers

PMID: 1862096
DOI: 10.1073/pnas.88.15.6716
PMCID: PMC52159

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