Article
DNA recombination and natural selection pressure sustain genetic sequence diversity of the feline MHC class I genes.
The Journal of experimental medicine - 1 Aug 1990
Yuhki N, O'Brien S J
Abstract excerpt
Sequence comparisons of seven distinct MHC class I cDNA clones revealed that feline class I molecules have a remarkable similarity to human HLA genes in their organization of functional domains as well as in the nonrandom partitioning of genetic variability according to the functional constraints...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cats
- Cloning, Molecular
- DNA
- Gene Library
- Genes, MHC Class I
- Genetic Variation
- Humans
- Molecular Sequence Data
- Protein Conformation
- RNA
- Recombination, Genetic
- Selection, Genetic
- Sequence Homology, Nucleic Acid
- Spleen