Article
Ancestral polymorphism of Mhc class II genes in mice: implications for balancing selection and the mammalian molecular clock.
Genetics - 1 Jun 1997
Edwards S V, Chesnut K, Satta Y, Wakeland E K
Abstract excerpt
To investigate the evolutionary dynamics at Mhc class II DR genes of mice (genus Mus), we sequenced the peptide binding regions (PBRs) of 41 DRB (= E beta) genes and eight DRA (= E alpha) genes from 15 strains representing eight species. As expected trees of these PBR sequences imply extensive maintenance of ancestral DRB alleles across species. We use a coalescent simulation model to show that the number of...
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