Ancestral polymorphism of Mhc class II genes in mice: implications for balancing selection and the mammalian molecular clock.

doi:10.1093/genetics/146.2.655

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Article

Ancestral polymorphism of Mhc class II genes in mice: implications for balancing selection and the mammalian molecular clock.

Genetics - 1 Jun 1997

Edwards S V, Chesnut K, Satta Y, Wakeland E K

Abstract excerpt

To investigate the evolutionary dynamics at Mhc class II DR genes of mice (genus Mus), we sequenced the peptide binding regions (PBRs) of 41 DRB (= E beta) genes and eight DRA (= E alpha) genes from 15 strains representing eight species. As expected trees of these PBR sequences imply extensive ma...

Topics

Alleles
Animals
Binding Sites
Evolution, Molecular
Exons
Genes, MHC Class II
Mice
Molecular Sequence Data
Phylogeny
Polymorphism, Genetic
Protein Structure, Secondary
Selection, Genetic

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