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Article

Ancestral major histocompatibility complex DRB genes beget conserved patterns of localized polymorphisms.

Proceedings of the National Academy of Sciences of the United States of America - 28 May 1996

Gaur L K, Nepom G T

Abstract excerpt

Genes within the major histocompatibility complex (MHC) are characterized by extensive polymorphism within species and also by a remarkable conservation of contemporary human allelic sequences in evolutionarily distant primates. Mechanisms proposed to account for strict nucleotide conservation in the context of highly variable genes include the suggestion that intergenic exchange generates repeated sets of MHC...

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Identifiers

PMID: 8643583
DOI: 10.1073/pnas.93.11.5380
PMCID: PMC39254

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