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Article

P-TEFb is not an essential elongation factor for the intronless human U2 snRNA and histone H2b genes.

The EMBO journal - 7 Dec 2005

Medlin Joanne, Scurry Andrew, Taylor Alice, Zhang Fan, Peterlin B Matija, Murphy Shona

Abstract excerpt

Phosphorylation of Ser2 of the heptapeptide repeat of the CTD of mammalian pol II by P-TEFb is associated with productive elongation of transcription of protein-coding genes. Here, we show that the CTD of pol II transcribing the human U2 snRNA genes is phosphorylated on Ser2 in vivo and that both the CDK9 kinase and cyclin T components of P-TEFb are required for cotranscriptional recognition of the 3' box RNA 3'...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16308568
DOI: 10.1038/sj.emboj.7600876
PMCID: PMC1356315

Genes

CDK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

P-TEFb is not an essential elongation factor for the intronless human U2 snRNA and histone H2b genes.PMID 16308568Read ↗

Phosphorylated positive transcription elongation factor b (P-TEFb) is tagged for inhibition through association with 7SK snRNA.Semantic proximity Read ↗

The human U1 snRNA promoter correctly initiates transcription in vitro and is activated by PSE1.Semantic proximity Read ↗

CK2 phosphorylation of Bdp1 executes cell cycle-specific RNA polymerase III transcription repression.Semantic proximity Read ↗

Regulation of P-TEFb elongation complex activity by CDK9 acetylation.Semantic proximity Read ↗

Interaction of proteins with promoter elements of the human U2 snRNA genes in vivo.Semantic proximity Read ↗

CDK-9/cyclin T (P-TEFb) is required in two postinitiation pathways for transcription in the C. elegans embryo.Semantic proximity Read ↗

A 10 residue motif at the C-terminus of the RNA pol II CTD is required for transcription, splicing and 3' end processing.Semantic proximity Read ↗

FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH.Semantic proximity Read ↗

[Role of SV40 T antigen binding sites within the 5' flanking region of human U1 and U2 snRNA genes].Semantic proximity Read ↗

P-TEFb containing cyclin K and Cdk9 can activate transcription via RNA.Semantic proximity Read ↗

In vivo structure of two divergent promoters at the human PCNA locus. Synthesis of antisense RNA and S phase-dependent binding of E2F complexes in intron 1.Semantic proximity Read ↗

U6 snRNA genes of Arabidopsis are transcribed by RNA polymerase III but contain the same two upstream promoter elements as RNA polymerase II-transcribed U-snRNA genes.Semantic proximity Read ↗

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