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Article

A 10 residue motif at the C-terminus of the RNA pol II CTD is required for transcription, splicing and 3' end processing.

The EMBO journal - 15 Aug 2003

Fong Nova, Bird Gregory, Vigneron Marc, Bentley David L

Abstract excerpt

The RNA polymerase II C-terminal heptad repeat domain (CTD) is essential for normal transcription and co-transcriptional processing of mRNA precursors. The mammalian CTD comprises 52 heptads whose consensus, YSPTSPS, is conserved throughout eukaryotes, followed by a 10 amino acid C-terminal sequence that is conserved only among vertebrates. Here we show that surprisingly, the heptad repeats are not sufficient to...

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Identifiers

PMID: 12912924
DOI: 10.1093/emboj/cdg396
PMCID: PMC175786

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Source receipt: pubmed, retrieved 7 Sept 2026.

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