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Article

Regulation of P-TEFb elongation complex activity by CDK9 acetylation.

Molecular and cellular biology - 1 Jul 2007

Fu Junjiang, Yoon Ho-Geun, Qin Jun, Wong Jiemin

Abstract excerpt

P-TEFb, comprised of CDK9 and a cyclin T subunit, is a global transcriptional elongation factor important for most RNA polymerase II (pol II) transcription. P-TEFb facilitates transcription elongation in part by phosphorylating Ser2 of the heptapeptide repeat of the carboxy-terminal domain (CTD) of the largest subunit of pol II. Previous studies have shown that P-TEFb is subjected to negative regulation by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17452463
DOI: 10.1128/MCB.00857-06
PMCID: PMC1951478

Genes

CDK9
HEXIM1
HDAC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Regulation of P-TEFb elongation complex activity by CDK9 acetylation.PMID 17452463Read ↗

Acetylation of cyclin T1 regulates the equilibrium between active and inactive P-TEFb in cells.Semantic proximity Read ↗

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CDK9: A key player in cancer and other diseasesSemantic proximity Read ↗

Distinct Cdk9-phosphatase switches act at the beginning and end of elongation by RNA polymerase IISemantic proximity Read ↗

Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor.Semantic proximity Read ↗

Catalytic activity of Cdk9 is required for nuclear co-localization of the Cdk9/cyclin T1 (P-TEFb) complex.Semantic proximity Read ↗

Acetylation on histone H3 lysine 9 mediates a switch from transcription initiation to elongation.Semantic proximity Read ↗

Effects of prostratin on Cyclin T1/P-TEFb function and the gene expression profile in primary resting CD4+T cellsSemantic proximity Read ↗

The Myc transactivation domain promotes global phosphorylation of the RNA polymerase II carboxy-terminal domain independently of direct DNA binding.Semantic proximity Read ↗

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