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Article

FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH.

Molecular cell - 1 Jun 2000

Wada T, Orphanides G, Hasegawa J, Kim D K, Shima D, Yamaguchi Y, Fukuda A, Hisatake K, Oh S, Reinberg D, Handa H

Abstract excerpt

We report that the chromatin-specific transcription elongation factor FACT functions in conjunction with the RNA polymerase II CTD kinase P-TEFb to alleviate transcription inhibition by DSIF (DRB sensitivity-inducing factor) and NELF (negative elongation factor). We find that the kinase activity of TFIIH is dispensable for this activity, demonstrating that TFIIH-mediated CTD phosphorylation is not involved in the...

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Identifiers

PMID: 10912001
DOI: 10.1016/s1097-2765(00)80272-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH.PMID 10912001Read ↗

DSIF, the Paf1 complex, and Tat-SF1 have nonredundant, cooperative roles in RNA polymerase II elongation.Semantic proximity Read ↗

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The essential and multifunctional TFIIH complexSemantic proximity Read ↗

FACT and the reorganized nucleosome.Semantic proximity Read ↗

The general transcription factor TFIIB is a target for transcriptome control during cellular stress and viral infectionSemantic proximity Read ↗

The yeast and human FACT chromatin-reorganizing complexes solve R-loop-mediated transcription-replication conflicts.Semantic proximity Read ↗

Distinct Cdk9-phosphatase switches act at the beginning and end of elongation by RNA polymerase IISemantic proximity Read ↗

Essential histone chaperones collaborate to regulate transcription and chromatin integrity.Semantic proximity Read ↗

Single-molecule microscopy reveals that TFIIE subunits dynamically interact with preinitiation complexes in a manner controlled by TFIIHSemantic proximity Read ↗

Dynamics of Human Immunodeficiency Virus Transcription: P-TEFb Phosphorylates RD and Dissociates Negative Effectors from the Transactivation Response ElementSemantic proximity Read ↗

RNA polymerase II initiation factors show different dynamic behaviour upon induced transcription in live cellsSemantic proximity Read ↗

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