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Article

A functional variant in the human betacellulin gene promoter is associated with type 2 diabetes.

Diabetes - 1 Dec 2005

Nakano Yoshio, Furuta Hiroto, Doi Asako, Matsuno Shohei, Nakagawa Takayuki, Shimomura Hiroko, Sakagashira Setsuya, Horikawa Yukio, Nishi Masahiro, Sasaki Hideyuki, Sanke Tokio, Nanjo Kishio

Abstract excerpt

Betacellulin (BTC) plays an important role in differentiation, growth, and antiapoptosis of pancreatic beta-cells. We characterized about 2.3 kb of the 5'-flanking region of human BTC gene and identified six polymorphisms (-2159A>G, -1449G>A, -1388C>T, -279C>A, -233G>C, and -226A>G). The G allele in the -226A>G polymorphism was more frequent in type 2 diabetic patients (n = 250) than in nondiabetic subjects (n =...

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Identifiers

PMID: 16306376
DOI: 10.2337/diabetes.54.12.3560

Genes

BTC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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