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Article

Association between promoter polymorphisms of the GRP78 gene and risk of type 2 diabetes in a Chinese Han population.

DNA and cell biology - 1 Mar 2013

Liu Shengyuan, Li Keshen, Li Tao, Xiong Xingdong, Yao Songpo, Chen Zhongwei, Wang Changyi, Zhao Bin

Abstract excerpt

There are large amounts of unfolding or misfolding protein accumulation in the endoplasmic reticulum in patients with type 2 diabetes (T2D), which in turn induces the expression of the glucose-regulated protein 78 (GRP78) that plays a key role in influencing insulin secretion and maintaining glucose homeostasis in pancreatic beta cells. The aim in the study is to analyze the potential association between...

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Identifiers

PMID: 23402331
DOI: 10.1089/dna.2012.1909
PMCID: PMC3589892

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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