Article
Identification of a functional protein kinase Cbeta promoter polymorphism in humans related to insulin resistance.
Molecular genetics and metabolism - 1 Feb 2008
Osterhoff Martin A, Heuer Susanne, Pfeiffer Michaela, Tasic Jelena, Kaiser Simone, Isken Frank, Spranger Joachim, Weickert Martin O, Möhlig Matthias, Pfeiffer Andreas F H
Abstract excerpt
Protein kinase Cbeta (PKCbeta) is known to inhibit insulin production in beta-cells and to support insulin action in skeletal muscle. We therefore searched for functional polymorphisms among already known genetic variants in the PKCbeta promoter and investigated their relation to glucose metabolism in humans. We found that the gene variant in the PKCbeta promoter at position -546 significantly reduced promoter...
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