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Article

A variation at position -30 of the beta-cell glucokinase gene promoter is associated with reduced beta-cell function in middle-aged Japanese-American men.

Diabetes - 1 Apr 1996

Stone L M, Kahn S E, Fujimoto W Y, Deeb S S, Porte D

Abstract excerpt

We sought to determine whether a G -> A variant at position -30 of the beta-cell promoter of the glucokinase (GCK) gene observed to be present more frequently in Japanese-American men with impaired glucose tolerance (IGT) than in Japanese-American men with normal glucose tolerance (NGT) is associated with impaired beta-cell function. We studied 125 unrelated Japanese-American men (aged 46-74 years; mean 61 +/-...

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Source

Identifiers

PMID: 8603762
DOI: 10.2337/diab.45.4.422

Genes

GCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A variation at position -30 of the beta-cell glucokinase gene promoter is associated with reduced beta-cell function in middle-aged Japanese-American men.PMID 8603762Read ↗

A -30G>A polymorphism of the beta-cell-specific glucokinase promoter associates with hyperglycemia in the general population of whites.Semantic proximity Read ↗

Clinical characteristics of Japanese men with glucokinase gene beta-cell promoter variant.Semantic proximity Read ↗

The g/a nucleotide variant at position -30 in the beta-cell-specific glucokinase gene promoter has no impact on the beta-cell function in Danish Caucasians.Semantic proximity Read ↗

Glucokinase gene islet promoter region variant (G-->A) at nucleotide -30 is not associated with reduced insulin secretion in Finns.Semantic proximity Read ↗

Glucokinase gene variations in Japanese-Americans with a family history of NIDDM.Semantic proximity Read ↗

Analysis of the glucokinase gene promoter in Japanese subjects with noninsulin-dependent diabetes mellitus.Semantic proximity Read ↗

The beta cell glucokinase promoter variant is an unlikely risk factor for diabetes mellitus. Diabetes Incidence Study in Sweden (DISS).Semantic proximity Read ↗

Glucokinase gene variants in subjects with late-onset NIDDM and impaired glucose tolerance.Semantic proximity Read ↗

Association of the glucokinase gene promoter polymorphism -30G > A (rs1799884) with gestational diabetes mellitus susceptibility: a case-control study and meta-analysis.Semantic proximity Read ↗

G(-30)A polymorphism in the pancreatic promoter of the glucokinase gene associated with angiographic coronary artery disease and type 2 diabetes mellitus.Semantic proximity Read ↗

A functional variant in the human betacellulin gene promoter is associated with type 2 diabetes.Semantic proximity Read ↗

Homozygosity for a common polymorphism in the islet-specific promoter of the glucokinase gene is associated with a reduced early insulin response to oral glucose in pregnant women.Semantic proximity Read ↗

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