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The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49 279 subjects.

Human molecular genetics - 1 Jul 2009

Choquet Hélène, Cavalcanti-Proença Christine, Lecoeur Cécile, Dina Christian, Cauchi Stéphane, Vaxillaire Martine, Hadjadj Samy, Horber Fritz, Potoczna Natasha, Charpentier Guillaume, Ruiz Juan, Hercberg Serge, Maimaitiming Suliya, Roussel Ronan, Boenhnke Michael, Jackson Anne U, Patsch Wolfgang, Krempler Franz, Voight Benjamin F, Altshuler David, Groop Leif, Thorleifsson Gudmar, Steinthorsdottir Valgerdur, Stefansson Kari, Balkau Beverley, Froguel Philippe, Meyre David

Abstract excerpt

A recent study reported an association between the brain natriuretic peptide (BNP) promoter T-381C polymorphism (rs198389) and protection against type 2 diabetes (T2D). As replication in several studies is mandatory to confirm genetic results, we analyzed the T-381C polymorphism in seven independent case-control cohorts and in 291 T2D-enriched pedigrees totalling 39 557 subjects of European origin. A...

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PMID: 19377085
DOI: 10.1093/hmg/ddp169

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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