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Article

Association of a polymorphism in the betacellulin gene with type 1 diabetes mellitus in two populations.

Journal of molecular medicine (Berlin, Germany) - 1 Jul 2006

Silver Kristi D, Magnuson Victoria L, Tolea Magdalena, Wang Jian, Hagopian William A, Mitchell Braxton D

Abstract excerpt

Betacellulin, a member of the epidermal growth factor family, is expressed in fetal and adult pancreas. In vitro and in vivo studies suggest a role for betacellulin in islet neogenesis and regeneration. Therefore, a mutation in the betacellulin gene might lead to fewer beta cells. With reduced beta cell reserve, beta cells may not be able to compensate for an autoimmune attack, and in turn, susceptibility to type...

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PMID: 16683131
DOI: 10.1007/s00109-006-0052-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association of a polymorphism in the betacellulin gene with type 1 diabetes mellitus in two populations.PMID 16683131Read ↗

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