Article
Molecular scanning of the betacellulin gene for mutations in type 2 diabetic patients.
Diabetes research and clinical practice - 1 Jun 2005
Nakagawa Takayuki, Furuta Hiroto, Sanke Tokio, Sakagashira Setuya, Shimomura Hiroko, Shimajiri Yoshinori, Hanabusa Tadashi, Nishi Masahiro, Sasaki Hideyuki, Nanjo Kishio
Abstract excerpt
Betacellulin (BTC), a member of the epidermal growth factor (EGF) family, is an important factor in the growth and/or differentiation of pancreatic beta cells. In this point of view, we determined the transcriptional start site of the human BTC gene and screened the protein-coding region for mutations. The transcriptional start site was located 347 bp upstream from the translational initiation codon. After...
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