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Functional polymorphism of hOGG1 gene is associated with type 2 diabetes mellitus in Chinese population.

Molecular and cellular endocrinology - 30 Aug 2010

Sun Caixia, Liu Xiufang, Zhang Huan, Guo Wenwen, Cai Zhenming, Chen Huimei, Zhang Kui, Zhu Dalong, Wang Yaping

Abstract excerpt

hOGG1 protein excises the 8-hydroxy-2'-deoxyguanine (8-OHdG) which is associated with type 2 diabetes mellitus (T2DM). Our aim of this work is to explore whether the polymorphisms of hOGG1 gene are associated with T2DM. We screened the polymorphisms in the 5'-UTR (c.-18G>T, c.-23A>G, c.-45G>A and c.-53G>C) and c.977C>G (Ser326Cys) in exon 7 of hOGG1 gene. A case-control study indicated that c.-23A/G heterozygote...

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PMID: 20562008
DOI: 10.1016/j.mce.2010.05.005

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