Elevated synaptic activity preconditions neurons against an in vitro model of ischemia.

doi:10.1074/jbc.M805624200

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Article

Elevated synaptic activity preconditions neurons against an in vitro model of ischemia.

The Journal of biological chemistry - 12 Dec 2008

Tauskela Joseph S, Fang Hung, Hewitt Melissa, Brunette Eric, Ahuja Tarun, Thivierge Jean-Philippe, Comas Tanya, Mealing Geoffrey A R

Abstract excerpt

Tolerance to otherwise lethal cerebral ischemia in vivo or to oxygen-glucose deprivation (OGD) in vitro can be induced by prior transient exposure to N-methyl-D-aspartic acid (NMDA): preconditioning in this manner activates extrasynaptic and synaptic NMDA receptors and can require bringing neurons to the "brink of death." We considered if this stressful requirement could be minimized by the stimulation of...

Topics

Animals
Brain
Brain Ischemia
Calcium
In Vitro Techniques
Ischemic Preconditioning
Microscopy, Fluorescence
Mitogen-Activated Protein Kinase 1
Mitogen-Activated Protein Kinase 3
Models, Biological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neurons

Phenotype

Rats

Receptors, N-Methyl-D-Aspartate

Synapses

Tetrodotoxin

Source

Open in PubMed Open full text

Identifiers

PMID: 18845540
DOI: 10.1074/jbc.M805624200
PMCID: PMC3259903

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