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Article

Toxoplasma gondii-specific immunoglobulin M limits parasite dissemination by preventing host cell invasion.

Infection and immunity - 1 Dec 2005

Couper Kevin N, Roberts Craig W, Brombacher Frank, Alexander James, Johnson Lawrence L

Abstract excerpt

An important role for immunoglobulin M (IgM) during early acute virulent Toxoplasma gondii infection was identified using IgM-/- mice that lack surface and secretory IgM but maintain normal B-cell functionality and isotype class switching. Following intraperitoneal inoculation with the virulent RH strain, IgM-/- mice displayed significantly fewer peritoneal parasites than wild-type (WT) mice, which correlated...

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Identifiers

PMID: 16299300
DOI: 10.1128/IAI.73.12.8060-8068.2005
PMCID: PMC1307022

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Source receipt: pubmed, retrieved 7 Sept 2026.

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