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Article

The absence of serum IgM enhances the susceptibility of mice to pulmonary challenge with Cryptococcus neoformans.

Journal of immunology (Baltimore, Md. : 1950) - 15 May 2010

Subramaniam Krishanthi S, Datta Kausik, Quintero Eric, Manix Catherine, Marks Matthew S, Pirofski Liise-Anne

Abstract excerpt

The importance of T cell-mediated immunity for resistance to the disease (cryptococcal disease) caused by Cryptococcus neoformans is incontrovertible, but whether Ab immunity also contributes to resistance remains uncertain. To investigate the role of IgM in resistance to C. neoformans, we compared the survival, fungal burden, lung and brain inflammatory responses, and lung phagocytic response of sIgM(-/-) mice,...

Topics

Animals
Antibodies, Bacterial
Cryptococcosis
Cryptococcus neoformans
Genetic Predisposition to Disease
Immunoglobulin M
Lung
Lung Diseases, Fungal
Mice
Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Knockout

Up-Regulation

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Identifiers

PMID: 20404271
DOI: 10.4049/jimmunol.0901638
PMCID: PMC2885446

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-20404271-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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