Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Toxoplasma gondii genotype determines MyD88-dependent signaling in infected macrophages.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2006

Kim Leesun, Butcher Barbara A, Lee Chiang W, Uematsu Satoshi, Akira Shizuo, Denkers Eric Y

Abstract excerpt

Infection of mouse macrophages with Toxoplasma gondii elicits MAPK activation and IL-12 production, but host cell signaling pathways have not been clearly delineated. Here, we compared macrophage signaling in response to high virulence type I (RH) vs low virulence type II (ME49) strain infection. Tachyzoites of both strains induced p38 MAPK-dependent macrophage IL-12 release, although ME49 elicited 2- to 3-fold...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Enzyme Activation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunity, Innate

Share to Interleukin-12

Share to Macrophages

Share to Myeloid Differentiation Factor 88

Share to p38 Mitogen-Activated Protein Kinases

Share to Toxoplasma

Source

Identifiers

PMID: 16888020
DOI: 10.4049/jimmunol.177.4.2584

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Toxoplasma gondii genotype determines MyD88-dependent signaling in infected macrophages.PMID 16888020Read ↗

Production of IL-12 by macrophages infected with Toxoplasma gondii depends on the parasite genotype.Semantic proximity Read ↗

Effects of Toxoplasma gondii genotype and absence of host MAL/Myd88 on the temporal regulation of gene expression in infected microglial cells.Semantic proximity Read ↗

Toxoplasma gondii induction of interleukin-12 is associated with acute virulence in mice and depends on the host genotype.Semantic proximity Read ↗

Transcriptional Analysis of Murine Macrophages Infected with Different <i>Toxoplasma</i> Strains Identifies Novel Regulation of Host Signaling PathwaysSemantic proximity Read ↗

Toxoplasma gondii: Cytokine responses in mice reinfected with atypical strains.Semantic proximity Read ↗

Dissemination of Toxoplasma gondii to immunoprivileged organs and role of Toll/interleukin-1 receptor signalling for host resistance assessed by in vivo bioluminescence imagingSemantic proximity Read ↗

<i>Toxoplasma</i> induced cytokine release syndrome is critically dependent on the expression of pore-forming Perforin-Like Protein-1Semantic proximity Read ↗

Toxoplasma gondii rhoptry protein38 (TgROP38) affects parasite invasion, egress, and induces IL-18 secretion during early infection.Semantic proximity Read ↗

The role of macrophages in protective and pathological responses to Toxoplasma gondiiSemantic proximity Read ↗

Early immune responses and parasite tissue distribution in mice experimentally infected with oocysts of either archetypal or non-archetypal genotypes of Toxoplasma gondii.Semantic proximity Read ↗

Phosphorylation of Immunity-Related GTPases by a Toxoplasma gondii-Secreted Kinase Promotes Macrophage Survival and VirulenceSemantic proximity Read ↗

Macrophage migration inhibitory factor (MIF) is critical for the host resistance against Toxoplasma gondii.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.