Article
The role of MHC haplotypes H2d/H2b in mouse resistance/susceptibility to cyst formation is influenced by the lineage of infective Toxoplasma gondii strain.
Anais da Academia Brasileira de Ciencias - 1 Mar 2008
Resende Marianne G, Fux Blima, Caetano Brália C, Mendes Erica A, Silva Neide M, Ferreira Adriana M, Melo Maria Norma, Vitor Ricardo W A, Gazzinelli Ricardo T
Abstract excerpt
Toxoplasma gondii strains displaying the Type I/III genotype are associated with acquired ocular toxoplasmosis in humans. Here, we used a mice model to characterize some immunological mechanisms involved in host resistance to infection with such strains. We have chosen the Type I/III strains D8, G2 and P-Br, which cause a chronic infection in mice that resembles human toxoplamosis. Mice deficient of molecules...
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