Article
IgM, Fc mu Rs, and malarial immune evasion.
Journal of immunology (Baltimore, Md. : 1950) - 1 May 2010
Czajkowsky Daniel M, Salanti Ali, Ditlev Sisse B, Shao Zhifeng, Ghumra Ashfaq, Rowe J Alexandra, Pleass Richard J
Abstract excerpt
IgM is an ancestral Ab class found in all jawed vertebrates, from sharks to mammals. This ancient ancestry is shared by malaria parasites (genus Plasmodium) that infect all classes of terrestrial vertebrates with whom they coevolved. IgM, the least studied and most enigmatic of the vertebrate Igs, was recently shown to form an intimate relationship with the malaria parasite Plasmodium falciparum. In this article,...
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