Bradyzoite-Specific Surface Antigen SRS9 Plays a Role in Maintaining <i>Toxoplasma gondii</i> Persistence in the Brain and in Host Control of Parasite Replication in the Intestine

Abstract excerpt

Toxoplasma gondii is a ubiquitous parasite that persists for the life of a healthy mammalian host. A latent, chronic infection can reactivate upon immunosuppression and cause life-threatening diseases, such as encephalitis. A key to the pathogenesis is the parasite's interconversion between the tachyzoite (in acute infection) and bradyzoite (in chronic infection) stages. This developmental switch is marked by...

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