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Antigen-Driven Induction of Polyreactive IgM during Intracellular Bacterial Infection

23 Jun 2012

Abstract excerpt

Polyreactivity is well known as a property of natural IgM produced by B-1 cells. We demonstrate that polyreactive IgM is also generated during infection of mice with Ehrlichia muris, a tick-borne intracellular bacterial pathogen. The polyreactive IgM bound self and foreign Ags, including single-stranded and double-stranded DNA, insulin, thyroglobulin, LPS, influenza virus, and Borrelia burgdorferi. Production of...

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PMID: 22730531
DOI: 10.4049/jimmunol.1200878

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