Article
Expression of aberrant forms of CD22 on B lymphocytes in Cd22a lupus-prone mice affects ligand binding.
International immunology - 1 Jan 2006
Nitschke Lars, Lajaunias Frédéric, Moll Thomas, Ho Liza, Martinez-Soria Eduardo, Kikuchi Shuichi, Santiago-Raber Marie-Laure, Dix Carolin, Parkhouse R Michael E, Izui Shozo
Abstract excerpt
CD22 functions primarily as a negative regulator of B-cell receptor signaling. The Cd22a allele has been proposed as a candidate allele for murine systemic lupus erythematosus. In this study, we explored the possible expression of aberrant forms of CD22, which differ in the N-terminal sequences constituting the ligand-binding site due to synthesis of abnormally processed Cd22 mRNA, in several Cd22a mouse strains,...
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