Article
Increased red cell turnover in a line of CD22-deficient mice is caused by Gpi1c: a model for hereditary haemolytic anaemia.
European journal of immunology - 1 Dec 2012
Walker Jennifer A, Hall Andrew M, Kotsopoulou Ekaterini, Espeli Marion, Nitschke Lars, Barker Robert N, Lyons Paul A, Smith Kenneth G C
Abstract excerpt
CD22, an inhibitory co-receptor of the BCR, has been identified as a potential candidate gene for the development of autoimmune haemolytic anaemia in mice. In this study, we have examined Cd22(tm1Msn) CD22-deficient mice and identified an increase in RBC turnover and stress erythropoiesis, which might be consistent with haemolysis. We then, however, eliminated CD22 deficiency as the cause of accelerated RBC...
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