Article
Amplified B lymphocyte CD40 signaling drives regulatory B10 cell expansion in mice.
PloS one - 1 Jan 2011
Poe Jonathan C, Smith Susan H, Haas Karen M, Yanaba Koichi, Tsubata Takeshi, Matsushita Takashi, Tedder Thomas F
Abstract excerpt
BACKGROUND: Aberrant CD40 ligand (CD154) expression occurs on both T cells and B cells in human lupus patients, which is suggested to enhance B cell CD40 signaling and play a role in disease pathogenesis. Transgenic mice expressing CD154 by their B cells (CD154(TG)) have an expanded spleen B cell pool and produce autoantibodies (autoAbs). CD22 deficient (CD22(-/-)) mice also produce autoAbs, and importantly,...
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