Article
Structure and function of CD72 in the non-obese diabetic (NOD) mouse.
Autoimmunity - 1 Jun 2003
Rojas Andres, Xu Fingping, Rojas Mauricio, Thomas James W
Abstract excerpt
Type I or insulin dependent diabetes mellitus develops in the non-obese diabetic (NOD) mouse as a consequence of T cell mediated autoimmune attack on pancreatic beta cells. B lymphocytes are required for disease progression in NOD and loss of tolerance in the B cell compartment is one of the earliest manifestation of the autoimmune process. To understand how the fate and function of B lymphocytes may be regulated...
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