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Article

Ablation of CD22 in ligand-deficient mice restores B cell receptor signaling.

Nature immunology - 1 Feb 2006

Collins Brian E, Smith Brian A, Bengtson Per, Paulson James C

Abstract excerpt

CD22 is a negative regulator of B cell signaling, an activity modulated by its interaction with glycan ligands containing alpha2-6-linked sialic acids. B cells deficient in the enzyme (ST6Gal I) that forms the CD22 ligand show suppressed BCR signaling. Here we report that mice deficient in both CD22 and its ligand (Cd22-/- St6gal1-/- mice) showed restored B cell receptor (BCR) signaling, suggesting that the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16369536
DOI: 10.1038/ni1283

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Ablation of CD22 in ligand-deficient mice restores B cell receptor signaling.PMID 16369536Read ↗

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CD22 and Autoimmune DiseaseSemantic proximity Read ↗

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