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Article

Peripheral B cell receptor editing may promote the production of high-affinity autoantibodies in CD22-deficient mice.

European journal of immunology - 1 Oct 2006

Yarkoni Yuval, Fischel Ruth, Kat Inbal, Yachimovich-Cohen Nurit, Eilat Dan

Abstract excerpt

CD22-deficient mice are characterized by B cell hyperactivity and autoimmunity. We have constructed knock-in CD22-/- mice, expressing an anti-DNA heavy (H) chain (D42), alone or combined with Vkappa1-Jkappa1 or Vkappa8-Jkappa5 light (L) chains. The Ig-targeted mice produced a lupus-like serology that was age- and sex-dependent. High-affinity IgG autoantibodies were largely dependent on the selection of B cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Rearrangement, B-Lymphocyte

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Share to Lupus Erythematosus, Systemic

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Share to Receptors, Antigen, B-Cell

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Source

Identifiers

PMID: 16983722
DOI: 10.1002/eji.200636190

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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