Article
3'UTR/T polymorphism of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is associated with modified anti-platelet activity of atorvastatin in hypercholesterolemic subjects.
Atherosclerosis - 1 Dec 2005
Puccetti Luca, Pasqui Anna Laura, Pastorelli Marcello, Ciani Federica, Palazzuoli Alberto, Gioffrè Walter, Auteri Alberto, Bruni Fulvio
Abstract excerpt
Oxidized-low density lipoproteins (ox-LDL) and the specific receptor LOX-1 are involved in atherogenesis and atherothrombosis. LOX-1 downregulation is associated with the anti-platelet action of atorvastatin. 3'UTR/T LOX-1 polymorphism has been associated with increased risk of coronary artery disease. This study was planned to determine whether LOX-1 genetic variations could affect anti-platelet action of...
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