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Article

An intronic polymorphism in the PAR-1 gene is associated with platelet receptor density and the response to SFLLRN.

Blood - 1 Mar 2003

Dupont Annabelle, Fontana Pierre, Bachelot-Loza Christilla, Reny Jean-Luc, Biéche Ivan, Desvard Florence, Aiach Martine, Gaussem Pascale

Abstract excerpt

Protease-activated receptor 1 (PAR-1), the main thrombin receptor on vascular cells, plays a key role in platelet activation. We examined the range of PAR-1 expression on platelets, obtained twice, 1 week apart, from 100 healthy subjects and found a 2-fold interindividual variation in receptor numbers (95% CI = 858-1700). Because PAR-1 density was stable with time (r(2) = 76%, P <.001), we sought a genetic...

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Source

Identifiers

PMID: 12406873
DOI: 10.1182/blood-2002-07-2149

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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