Article
Platelet CD36 surface expression levels affect functional responses to oxidized LDL and are associated with inheritance of specific genetic polymorphisms.
Blood - 9 Jun 2011
Ghosh Arunima, Murugesan Gurunathan, Chen Kan, Zhang Li, Wang Qing, Febbraio Maria, Anselmo Rita Marie, Marchant Kandice, Barnard John, Silverstein Roy L
Abstract excerpt
CD36 modulates platelet function via binding to oxidized LDL (oxLDL), cell-derived microparticles, and thrombospondin-1. We hypothesized that the level of platelet CD36 expression may be associated with inheritance of specific genetic polymorphisms and that this would determine platelet reactivity to oxLDL. Analysis of more than 500 subjects revealed that CD36 expression levels were consistent in individual...
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