Article
A common polymorphism in the annexin V Kozak sequence (-1C>T) increases translation efficiency and plasma levels of annexin V, and decreases the risk of myocardial infarction in young patients.
Blood - 15 Sept 2002
González-Conejero Rocio, Corral Javier, Roldán Vanessa, Martínez Constantino, Marín Francisco, Rivera José, Iniesta Juan A, Lozano María L, Marco Pascual, Vicente Vicente
Abstract excerpt
Annexin V has phospholipid-binding capacity and plays a potent antithrombotic role. Recently, a C to T transition has been described in the Kozak region of this gene, affecting the nucleotide preceding the initiation ATG codon. We have developed a simple method to detect this genetic change, showing by analysis of 580 Mediterranean white subjects that the -1C to T transition (-1C>T) is a common polymorphism...
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