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Article

Impact of variables of the P-selectin - P-selectin glycoprotein ligand-1 axis on leukocyte-platelet interactions in cardiovascular disease.

Thrombosis and haemostasis - 1 Apr 2015

Gremmel Thomas, Koppensteiner Renate, Kaider Alexandra, Eichelberger Beate, Mannhalter Christine, Panzer Simon

Abstract excerpt

The formation of leukocyte-platelet aggregates (LPA), through the P-selectin - P-selectin glycoprotein ligand (PSGL)-1 axis, plays a pivotal role in atherothrombosis. In order to investigate the influence of platelet (pP-selectin) and soluble P-selectin (sP-selectin), and of variations in the genes encoding for P-selectin (SELP) and PSGL-1 (SELPLG) on LPA formation, we assessed monocyte (MPA)- and...

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Source

Identifiers

PMID: 25428141
DOI: 10.1160/TH14-08-0690

Genes

SELP
SELPLG
LPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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