Article
Variation in the human lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) gene is associated with plasma soluble LOX-1 levels.
Experimental physiology - 1 Sept 2008
Brinkley Tina E, Kume Noriaki, Mitsuoka Hirokazu, Brown Michael D, Phares Dana A, Ferrell Robert E, Kita Toru, Hagberg James M
Abstract excerpt
The lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) expressed on vascular cells plays a major role in atherogenesis by internalizing and degrading oxidized low-density lipoprotein. LOX-1 can be cleaved from the cell surface and released as soluble LOX-1 (sLOX-1), and elevated sLOX-1 levels may be indicative of atherosclerotic plaque instability. We examined associations between the LOX-1 gene...
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